SARMs Powder AICAR Acadesine for Bodybuilding CAS: 2627-69-2

Basic info:

Product Name: AICAR/ Acadesine

Full name: 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside

Alias: AICA Riboside; Acadesine

CAS: 2627-69-2

MF: C9H14N4O5

MW: 258.23

EINECS: 220-097-5

Appearance: White powder

Purity: 99.8%

Usage: Glucose uptake stimulant; AMPK activator; AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Aicar Product Description:

AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Aicar Function:

AICAR also known as ZMP is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity (AMPK). AICAR is being clinically used to treat and

protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct.

Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium .

The drug was first used in the 1980’s as a method to preserve blood flow to the heart during surgery. Currently,

the drug has also been shown as a potential treatment for diabetes by increasing the

metabolic activity of tissues by changing the physical composition of muscle.

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